Maklakov lab: Evolutionary biology of ageing
Research in our lab revolves around fundamental questions in evolutionary biology: Why do organisms age? How do they choose mates? How does learning evolve and is it costly? More specifically, we are interested in the evolution of life histories, conflicts between the sexes, sexual dimorphism and learning. These questions are often intimately linked: for example, to understand sexual dimorphism in longevity, one has to combine evolutionary theory of ageing with sexual selection theory. We work on a variety of different organisms: birds, beetles, flies, roundworms and humans, since our research is generally driven by the question rather than by the organism. Much of this work involves experimental studies in laboratory with small, fast-reproducing creatures but we also utilize privately or publicly available databases when it comes to populations of wild animals or humans.
The main focus of our current research is the evolutionary theory of ageing, which is a fundamental and, as yet, unresolved issue in biology. We pursue this line of research both theoretically and empirically using experimental evolution, next-generation sequencing, behavioural assays and long-term studies of natural populations. Currently we are very interested in i) the evolution of sex differences in lifespan and ageing; ii) the role of condition-dependent mortality in the evolution of ageing; and iii) the trade-off between learning and longevity.
(C. remanei photo courtesy of Kristin Sikkink)
New paper on late-acting deleterious alleles that have small but visible effects in early life. Link to the paper